Two hundred years after Mary Shelley's novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O'Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil. 在玛丽·雪莱的演义两百年后，能力横溢但跋扈的大夫使他自身和他的怪物从两个世纪前确首先的试探根本幸存下来。现在，美国探员 O'Connor 在调查系列谋杀案时，被引向了大夫和他的怪物，并露出出在长达两个多世纪的须臾韶华中，大夫和他故故品间的神奇转换和他们踏上善与恶的迥异阶梯。